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The principal cytochrome P450 isoenzyme included seems to generally be CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Somewhere around 85% of the oral dose seems from the urine in 24 hours of administration, most since the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity info.May